Auto-anti-idiotypic mechanisms can regulate the protective immune response against
Schistosoma mansoni. Anti-idiotypic responses were stimulated by immunization of mice
either with nonspecifically induced lymphoblasts, produced with Con A, or with Ag-induced
lymphoblasts bearing specific idiotypic receptors. The effect of the induced anti-idiotypic
response upon clonotypic cellular reactivity was assessed in vitro through the suppression
of antigen-mediated blast transformation by cloned T cells and in vivo by suppression of …

These studies explore auto-anti-idiotypic mechanisms as potential regulators of the
protective immune response against Schistosoma mansoni. Anti-idiotypic responses were
stimulated by immunization of mice with lymphoblasts, bearing specific idiotypic receptors.
These receptors were produced in vitro by stimulation of Ag-reactive T cells by soluble
cercarial immunogen, keyhole limpet hemocyanin, or Con A. The animals were then
exposed to irradiated cercariae, keyhole limpet hemocyanin, or SRBC. The results indicate …